The International Space Station was faced with a malfunctioning electrical unit, and astronauts couldn't screw down a new one because the exterior bolts were covered in debris. Then they got the idea of scrubbing the bolts clean with a toothbrush.
Testing everyone for HIV and then giving them early treatment could theoretically eliminate the epidemic in South Africa. A mathematical model of this "test and treat" strategy suggest that it might be more expensive and take significantly longer than previously predicted.
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