Of Neurons And Memories: Inside The 'Secret World Of Sleep' | WAMU 88.5 - American University Radio

Of Neurons And Memories: Inside The 'Secret World Of Sleep'

Play associated audio

What happens in our brains while we're asleep? That's one question neuroscientist Penelope Lewis is trying to answer. She directs the Sleep and Memory Lab at the University of Manchester in England. Her new book is The Secret World of Sleep: The Surprising Science of the Mind at Rest.

Lewis joins Fresh Air's Terry Gross to talk about how sleep affects memory, and how REM sleep can affect depression.


Interview Highlights

On how sleep makes memory stronger

"When it comes to strengthening [memory], we know that the neural responses in your brain that are associated with things you've recently experienced are spontaneously replayed, or, we say, 'reactivated' while you're asleep.

"So that means, supposing you are learning to play the piano ... you're moving your fingers a lot. That's associated with responses in motor areas of your brain. ... Those areas will become active again while you're asleep, and that replay — or reactivation — is what we think is responsible for the strengthening. So it's kind of like your brain is rehearsing stuff without you knowing, while you're asleep."

On the "spring cleaning" sleep does to the brain

"You clean up after you've made a mess, right? So that's exactly what sleep seems to do for the brain. ...

"Across the day while we're busy doing things, experiencing things, seeing things, hearing things, learning things, processing different kinds of information, the connections between neurons in the brain get strengthened because they're trying to retain all of this information. And an awful lot of it is garbage; it's stuff you don't want to remember or don't care about — what you had for breakfast, or the color of a stain on the cover of a book or something. It's really not useful or interesting.

"And the problem is, if you keep storing all of this stuff, you reach capacity and you can't keep storing more. And so what happens during sleep, and specifically during the deep stage of sleep that we call slow-wave sleep, is that all of those synapses get downscaled again. So where they've been strengthened up, they all get proportionally downscaled."

On treating depression by suppressing REM sleep

"In some people who are depressed, it's a good thing to suppress their REM [sleep] because REM is associated with specifically strengthening emotional memories, and in many cases negative memories. So there's an idea that it might be that in people who have too much REM, as many depressed people do, these negative memories are getting over-strengthened, and that can actually be quite damaging and quite pathological."

On what she hopes to learn about sleep

"My lab is particularly interested in how memories change while we're asleep. People might think that memories, once they're formed, they remain static and it's just kept like a library book on a shelf, and then you can pull it out when you want to. But actually that's not the case. Memories evolve constantly. They change, and a lot of that evolution seems to happen while you're asleep. ...

"We'd like to understand what sleep is really for. So, we spend one-third of our lives asleep as humans. That's a huge proportion. That's more time than we spend doing anything else. So it's got to be important for something. So part of the purpose of the research that I'm doing is trying to understand that. ...

"Another part of it is trying to understand something about memory. Memory is fundamental to the way our brains work. It's fundamental to our personalities, and there are an awful lot of unknown questions about memories. ... How they change over time, how do we extract this information? How do we go from an experience to having that experience integrated with everything else you know about the world?"

Copyright 2013 NPR. To see more, visit http://www.npr.org/.

WAMU 88.5

Art Beat With Lauren Landau, July 23

You can see a horror flick or attend a film festival about the events and heroes of the Civil Rights Movement.

NPR

Fruit Recall Hits Trader Joe's, Costco, Wal-Mart Stores

The recall applies to "certain lots of whole peaches (white and yellow), nectarines (white and yellow), plums and pluots" from a California packing company, the FDA says.
NPR

California Nurses Union Braces For Contract Battle

The largest union of nurses in California starts contract negotiations Thursday with Kaiser Permanente's hospitals. Talks went smoothly four years ago, but this round will likely be more contentious.
NPR

A Plan To Untangle Our Digital Lives After We're Gone

In the digital age, our online accounts don't die with us. A proposed law might determine what does happen to them. But the tech industry warns the measure could threaten the privacy of the deceased.

Leave a Comment

Help keep the conversation civil. Please refer to our Terms of Use and Code of Conduct before posting your comments.