Obama will address the 26 graduating seniors at Quantico Middle/High School, which serves the children of military service members.
The first lady's appearance there on June 3 will be her final stop on a four-school commencement tour this spring.
She will address graduates at the University of Northern Iowa, Spelman College in Atlanta and The United States Military Academy at West Point.
The White House says the schools share a deep commitment to service.
This is not be the first time Obama will address graduates at a local high school. In 2009 she spoke at The Washington Math Science Technology Public Charter School, and in 2010 she spoke at the Anacostia Senior High School graduation.