Virginia's attorney general, Ken Cuccinelli, was the lead panelist at a congressional hearing on Wednesday.
Cuccinelli underscored many of the same arguments presented in Virginia's lawsuit against the measure.
"It is the end of federalism as we have known it for over 220 years," Cuccinelli says.
Cuccinelli told the committee members that forcing Americans to buy health insurance is an attack against individual freedoms and states' rights.
"Once you have...kicked open that door, there is no articulable limit to that power," Cuccinelli added.
But the ranking Democrat on the House Judiciary Committee, Michigan's John Conyers disagreed.
"I want to assure you that the sky is not falling. I want to give you that assurance today that federalism is probably alive and well," Conyers says.
Duke University Law Professor Walter Dellinger argued that the mandate was neither intrusive nor unconstitutional.
"It's just the flip side of providing a tax credit, a modest tax credit for maintaining insurance, but having instead a modest tax penalty for not maintaining insurance. How is this the end of liberty as we know it?" Dellinger says.
The final answer to this question will most likely be provided by the Supreme Court.